BAX [Neurosurgery Wiki]

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=====BAX=====
[[Apoptosis]] regulator BAX, also known as [[bcl2]]-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the [[Bcl2]] gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. 

This protein forms a heterodimer with [[BCL2]], and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of [[cytochrome c]]. The expression of this gene is regulated by the tumor suppressor [[P53]] and has been shown to be involved in P53-mediated apoptosis.

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