Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. Base excision repair (BER) is a cellular mechanism, in [[DNA repair]] throughout the [[cell cycle]]. It is responsible primarily for removing small, non-helix-distorting base lesions from the [[genome]]. The related [[nucleotide]] excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing damaged bases that could otherwise cause [[mutation]]s by mispairing or lead to breaks during [[DNA replication]]. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2–10 new nucleotides are synthesized). base_excision_repair.txt Last modified: 2024/06/07 02:50by 127.0.0.1