Atypical meningioma outcome [Neurosurgery Wiki]

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====== Atypical meningioma outcome ======

In [[atypical meningioma]]s bone involvement and large [[meningioma peritumoral edema]] are associated with increased tumor progression.

[[Ki-67]] [[index]] >10% was associated with a trend toward worse PFS. Given the long-term survival, high recurrence rates, and efficacy of salvage therapy, patients with atypical and [[malignant meningioma]]s should be monitored systematically long after initial treatment
((Kent CL, Mowery YM, Babatunde O, Wright AO, Barak I, McSherry F, Herndon JE 2nd, Friedman AH, Zomorodi A, Peters K, Desjardins A, Friedman H, Sperduto W, Kirkpatrick JP. Long-Term Outcomes for Patients With Atypical or Malignant Meningiomas Treated With or Without Radiation Therapy: A 25-Year Retrospective Analysis of a Single-Institution Experience. Adv Radiat Oncol. 2021 Dec 24;7(3):100878. doi: 10.1016/j.adro.2021.100878. PMID: 35647401; PMCID: PMC9133398.)).
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The rarity and the inconsistent criteria for defining atypical meningioma prior to the WHO 2007 classification made its management and prognostic factors poorly understood. Only few articles have addressed the [[survival rate]]s of WHO-classified atypical meningiomas. The small number or the disproportionate representation of irradiated patients was a weakness for these articles.

The most important prognostic factor in determining recurrence was Simpson grading. There was no statistically significant impact of adjuvant radiotherapy on the recurrence of atypical meningiomas. [[Metaanalysis]] for the existing literature is needed
((Hammouche S, Clark S, Wong AH, Eldridge P, Farah JO. Long-term survival
analysis of atypical meningiomas: survival rates, prognostic factors, operative
and radiotherapy treatment. Acta Neurochir (Wien). 2014 Aug;156(8):1475-81. doi: 
10.1007/s00701-014-2156-z. Epub 2014 Jun 26. PubMed PMID: 24965072.)).

===== Recurrence =====

[[Atypical Meningioma Recurrence]].