Alzheimer's disease diagnosis [Neurosurgery Wiki]

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====== Alzheimer's disease diagnosis ======

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Extracellular [[amyloid-β]] (Aβ) [[plaque]]s and intracellular aggregates of [[tau protein]] in form of [[neurofibrillary tangles]] (NFT) are [[pathological hallmark]]s of Alzheimer's disease (AD).
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Brain imaging with [[positron emission tomography]] (PET) and [[cerebrospinal fluid]] (CSF) [[biomarker]] studies highlighted the long preclinical phase of AD in which a cascade of detectable biological abnormalities precede [[cognitive decline]]. The recent proliferation of imaging and fluid biomarkers of AD pathophysiology provides an opportunity for the identification of several biological stages in the preclinical phase of [[Alzheimer's disease]]
((Therriault J, Zimmer ER, Benedet AL, Pascoal TA, Gauthier S, Rosa-Neto P. Staging of Alzheimer's disease: past, present, and future perspectives. Trends Mol Med. 2022 Jun 15:S1471-4914(22)00137-X. doi: 10.1016/j.molmed.2022.05.008. Epub ahead of print. PMID: 35717526.)).

====== Positron emission tomography ======
[[Positron emission tomography for Alzheimer's disease diagnosis]]

===== Biomarkers =====

[[Alzheimer's disease biomarkers]].