Acinetobacter calcoaceticus [Neurosurgery Wiki]

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====== Acinetobacter calcoaceticus ======


[[Acinetobacter]] calcoaceticus is a bacterial species of the genus[[ Acinetobacter]]. It is a nonmotile, Gram-negative coccobacillus. It grows under aerobic conditions, is catalase positive and oxidase negative. A. calcoaceticus is a part of the A. calcoaceticus-A. baumannii complex together with [[Acinetobacter baumannii]], Acinetobacter nosocomialis, Acinetobacter pitti and Acinetobacter seifertii.
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Since the 1990s, [[antimicrobial resistance]] (AMR) has escalated dramatically among [[Acinetobacter baumannii]]-calcoaceticus complex [ABC]). Global spread of multidrug-resistant (MDR)-ABC strains reflects dissemination of a few clones between [[hospital]]s, geographic regions, and continents; excessive [[antibiotic]] use amplifies this spread. Many isolates are resistant to all antimicrobials except colistimethate sodium and [[tetracycline]]s ([[minocycline]] or [[tigecycline]]); some infections are untreatable with existing antimicrobial agents. AMR poses a serious threat to effectively treat or prevent ABC infections. Strategies to curtail environmental colonization with MDR-ABC require aggressive infection-control efforts and cohorting of infected patients. Thoughtful antibiotic strategies are essential to limit the spread of MDR-ABC. Optimal therapy will likely require combination antimicrobial therapy with existing [[antibiotic]]s as well as development of novel antibiotic classes
((Lynch JP 3rd, Clark NM, Zhanel GG. Infections Due to [[Acinetobacter baumannii]]-calcoaceticus Complex: Escalation of [[Antimicrobial Resistance]] and Evolving Treatment Options. Semin Respir Crit Care Med. 2022 Feb;43(1):97-124. doi: 10.1055/s-0041-1741019. Epub 2022 Feb 16. PMID: 35172361.)).
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