Show pageBacklinksExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== 3 + 3 design ====== The 3 + 3 design is a common approach in [[phase 1 trial]]s. It involves sequentially enrolling small groups of [[participant]]s, typically three participants per dose level, with a predefined dose escalation plan. If no dose-limiting toxicities (DLTs) occur in a group, the next group is enrolled at a higher dose. If a DLT occurs in one or more participants, the previous dose level is considered the maximum tolerated dose (MTD). 3_3_design.txt Last modified: 2025/05/13 02:19by 127.0.0.1