Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== 3 + 3 design ====== The 3 + 3 design is a common approach in [[phase 1 trial]]s. It involves sequentially enrolling small groups of [[participant]]s, typically three participants per dose level, with a predefined dose escalation plan. If no dose-limiting toxicities (DLTs) occur in a group, the next group is enrolled at a higher dose. If a DLT occurs in one or more participants, the previous dose level is considered the maximum tolerated dose (MTD). 3_3_design.txt Last modified: 2024/06/07 02:57by 127.0.0.1