2-Deoxy-D-glucose [Neurosurgery Wiki]

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====== 2-Deoxy-D-glucose ======

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2-Deoxy-D-[[glucose]] is a [[glucose]] molecule which has the 2-[[hydroxyl group]] replaced by [[hydrogen]], so that it cannot undergo further [[glycolysis]]. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labelled forms of [[2-Deoxy-D-glucose]] serve as a good marker for tissue glucose uptake and [[hexokinase]] activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.

see [[18F]]-[[fluorodeoxyglucose]]