11C methionine positron emission tomography for meningioma [Neurosurgery Wiki]

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====== 11C methionine positron emission tomography for meningioma ======

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Mitamura et al., evaluated the uptake of 2-deoxy-[[18F]]-[[Fludeoxyglucose]] ([[FDG]]) and L-[methyl-[[11C]]]-[[methionine]] ([[MET]]) in patients with newly diagnosed [[intracranial meningioma]]s and correlated the results with [[tumor]] [[proliferation]].

Data from 22 patients with newly diagnosed intracranial meningioma (12 grade I and 10 grade II) who underwent both FDG and MET brain [[PET/CT]] studies were retrospectively analyzed. The [[PET]] images were evaluated by a qualitative method and semiquantitative analysis using standardized uptake value (SUV) (SUVmax and SUVpeak) and tumor-to-reference tissue ratio (Tmax/N ratio and Tpeak/N ratio). Proliferative activity as indicated by the [[Ki-67]] index was estimated in tissue specimens.

MET PET/CT showed a higher detection rate of meningioma than did FDG PET/CT (100 vs. 46%, respectively). The Tmax/N ratio and Tpeak/N ratio on MET PET/CT were significantly higher than those on FDG PET/CT (p < 0.001 and p < 0.001, respectively). There was a significant difference between grades I and II with respect to FDG SUVmax (p = 0.003), FDG SUVpeak (p = 0.003), FDG Tmax/N ratio (p = 0.02), FDG Tpeak/N ratio (p = 0.006), MET SUVmax (p = 0.002), MET SUVpeak (p = 0.002), MET Tmax/N ratio (p = 0.002), and MET Tpeak/N ratio (p = 0.002). There was a significant correlation between Ki-67 index and FDG PET/CT for SUVmax (p = 0.02), SUVpeak (p = 0.005), and Tpeak/N ratio (p = 0.05) and between Ki-67 index and MET PET/CT for SUVmax (p = 0.004), SUVpeak (p = 0.007), Tmax/N ratio (p = 0.002), and Tpeak/N ratio (p = 0.004).

[[MET]] [[PET/CT]] showed a high [[sensitivity]] compared with [[FDG]] [[PET/CT]] for detection of newly diagnosed [[WHO grade]]s I and II [[intracranial meningioma]]s. Both FDG and MET uptake were found to be useful for evaluating tumor proliferation in meningiomas
((Mitamura K, Yamamoto Y, Norikane T, Hatakeyama T, Okada M, Nishiyama Y.
Correlation of (18)F-FDG and (11)C-methionine uptake on PET/CT with Ki-67
immunohistochemistry in newly diagnosed intracranial meningiomas. Ann Nucl Med.
2018 Jul 21. doi: 10.1007/s12149-018-1284-6. [Epub ahead of print] PubMed PMID:
30032455.
)).