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--- prospective_single-arm_cohort_study [2025/07/03 09:41] – created administrador
+++ prospective_single-arm_cohort_study [2025/07/03 09:44] (current) – administrador
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-A prospective single-arm cohort study is a type of observational clinical study with the following characteristics:
+====== Prospective single-arm cohort study ======
+A prospective [[single-arm]] [[cohort study]] is a type of [[observational]] clinical [[study]] with the following characteristics:
 ✅ Definition:
 A prospective single-arm cohort study follows a group of participants over time without a comparison (control) group, where all participants receive the same treatment or intervention, and outcomes are measured forward in time from the point of enrollment.
 🧠 Key Components:
 [[Prospective]]: Data is collected forward from a defined starting point (e.g., initiation of treatment).
@@ Line 14: / Line 18: @@
 📘 Example Use Case:
 Evaluating the safety and outcomes of a new surgical technique in 100 patients with Chiari I malformation, all treated the same way and followed for 12 months
 ((Henry LC, McDowell MM, Stephenson TL, Crittenden JB, Byrd AL, Fernández-de Thomas RJ, Chang YF, Nowicki KW, Mantena R, Strick PL, Friedlander RM. Predecompression and postdecompression cognitive and affective changes in Chiari malformation type I. J Neurosurg. 2025 Feb 21;143(1):4-12. doi: 10.3171/2024.8.JNS241363. PMID: 39983117.))
 ⚠️ Limitations:
-No control group limits ability to attribute causality.
-Susceptible to bias (e.g., selection bias, confounding).
+No control group limits ability to attribute [[causality]].
+Susceptible to [[bias]] (e.g., selection bias, confounding).
-Results are hypothesis-generating, not confirmatory.
+Results are [[hypothesis-generating]], not confirmatory.