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--- progression-free_survival [2025/07/03 06:34] – created administrador
+++ progression-free_survival [2025/07/03 06:35] (current) – administrador
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-====== Progression-Free Survival ======
+===== Progression-Free Survival =====
+**[[Progression]]-Free [[Survival]] (PFS)** is a clinical trial endpoint that measures the length of time during and after treatment that a patient lives with a disease (typically cancer) without it worsening.
+==== Definition ====
+PFS is defined as the time from the start of treatment (or randomization) until:
+  * **Objective disease progression**, as determined by standardized criteria (e.g., RECIST), or
+  * **Death from any cause**, whichever occurs first.
+==== Key Features ====
+  * Indicates the **period of disease control** under a given therapy.
+  * Does **not require death** to be observed.
+  * Commonly used in oncology trials as a **surrogate endpoint** for overall survival (OS), especially when OS is difficult to measure in a timely manner.
+  * Higher PFS values may suggest **greater efficacy** of the therapeutic intervention.
+==== Limitations ====
+  * May not always correlate with overall survival.
+  * Interpretation can be affected by **assessment intervals** and **imaging frequency**.
+  * Subject to **investigator bias** if not blinded.
+==== Related Terms ====
+  * [[Overall Survival (OS)]]
+  * [[Response Evaluation Criteria in Solid Tumors (RECIST)]]
+  * [[Disease-Free Survival (DFS)]]