plexiform_neurofibroma

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plexiform_neurofibroma [2025/07/18 05:48] – [2. Radiological Classification (based on MRI/CT)] administradorplexiform_neurofibroma [2025/07/18 05:51] (current) – [Clinical features] administrador
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 PubMed PMID: 9696077. PubMed PMID: 9696077.
 )). )).
 +
 +===== Imaging =====
 +  * **MRI**: Preferred modality. "Bag of worms" appearance; T2 hyperintense, poorly defined margins.
 +  * **CT**: Useful for bony remodeling or skull base involvement.
 +  * **PET-CT**: May assist in identifying malignant transformation (increased FDG uptake).
 +
 +===== Histology =====
 +  * Schwann cells, fibroblasts, mast cells, and extracellular matrix.
 +  * Immunohistochemistry: S100+, CD34+, variably.
  
 ==== 🩺 Management and Surveillance ==== ==== 🩺 Management and Surveillance ====
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