osteoarthritis_pathogenesis

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osteoarthritis_pathogenesis [2025/07/09 15:05] – [The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis] administradorosteoarthritis_pathogenesis [2025/07/09 15:05] (current) – [8. Emerging Concepts] administrador
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 Overall, osteoarthritis is a multifactorial disease with contributions from mechanical, biochemical, genetic, and environmental factors. Understanding the underlying mechanisms involved in OA pathogenesis is essential for developing effective strategies for prevention and treatment. Overall, osteoarthritis is a multifactorial disease with contributions from mechanical, biochemical, genetic, and environmental factors. Understanding the underlying mechanisms involved in OA pathogenesis is essential for developing effective strategies for prevention and treatment.
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 [[Transferrin receptor]]-1 (TfR1) plays important roles in controlling cellular [[iron]] levels, but its role in [[osteoarthritis]] pathology is unknown. [[Transferrin receptor]]-1 (TfR1) plays important roles in controlling cellular [[iron]] levels, but its role in [[osteoarthritis]] pathology is unknown.
 Wang et al. aim to investigate the role of TfR1 in OA progression and its underlying mechanisms. Wang et al. aim to investigate the role of TfR1 in OA progression and its underlying mechanisms.
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 Lin et al.   Lin et al.  
 from the Xiangya Hospital, Changsha   from the Xiangya Hospital, Changsha  
-published in the Journal of Pain Research  +published in the [[Journal of Pain Research]]  
 to investigate the causal relationship between circulating inflammatory proteins and [[osteoarthritis]] (OA) using Mendelian randomization and transcriptomic data. to investigate the causal relationship between circulating inflammatory proteins and [[osteoarthritis]] (OA) using Mendelian randomization and transcriptomic data.
 The study suggests causal roles for various inflammatory proteins in [[osteoarthritis pathogenesis]]. Certain proteins (e.g., interleukin-8, fractalkine) are associated with higher OA risk, while others (e.g., interleukin-10 receptor subunit alpha) correlate with lower risk. Additionally, OA itself may causally influence inflammatory protein levels, particularly in a joint-specific manner (hip vs knee). Six key OA-related inflammation-related genes (IRGs) were identified as potential biomarkers The study suggests causal roles for various inflammatory proteins in [[osteoarthritis pathogenesis]]. Certain proteins (e.g., interleukin-8, fractalkine) are associated with higher OA risk, while others (e.g., interleukin-10 receptor subunit alpha) correlate with lower risk. Additionally, OA itself may causally influence inflammatory protein levels, particularly in a joint-specific manner (hip vs knee). Six key OA-related inflammation-related genes (IRGs) were identified as potential biomarkers
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  • Last modified: 2025/07/09 15:05
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