egfr_inhibitor

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egfr_inhibitor [2025/05/15 07:13] – administradoregfr_inhibitor [Unknown date] (current) – external edit (Unknown date) 127.0.0.1
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 ====== EGFR inhibitor ====== ====== EGFR inhibitor ======
  
-===== Are EGFR Inhibitors the Same as Tyrosine Kinase Inhibitors (TKIs)? ===== 
  
-Not exactly. **All [[EGFR tyrosine kinase inhibitor]]s are EGFR inhibitors**, but **not all EGFR inhibitors are tyrosine kinase inhibitors (TKIs)**. +see [[Tyrosine kinase inhibitor]].
- +
-===== EGFR Inhibitors ===== +
-EGFR inhibitors refer to **any drug that blocks the activity of the epidermal growth factor receptor (EGFR)**. There are two main types: +
- +
-  * **Monoclonal Antibodies (mAbs):** +
-    * Target the **extracellular domain** of EGFR +
-    * Block ligand binding (e.g., EGF, amphiregulin) and prevent receptor dimerization +
-    * Examples: +
-      * **Cetuximab** +
-      * **Panitumumab** +
- +
-  * **Tyrosine Kinase Inhibitors (TKIs):** +
-    * Target the **intracellular kinase domain** of EGFR +
-    * Compete with ATP to block autophosphorylation and downstream signaling +
-    * Examples: +
-      * **Erlotinib** +
-      * **Gefitinib** +
-      * **Afatinib** +
-      * **Osimertinib** +
- +
-===== Tyrosine Kinase Inhibitors (TKIs) ===== +
-TKIs are a broader class of drugs that inhibit the kinase activity of **various receptor tyrosine kinases**, not just EGFR. Examples include: +
- +
-  * **EGFR-TKIs:** Erlotinib, Gefitinib +
-  * **VEGFR-TKIs:** Sunitinib, Sorafenib +
-  * **MET-TKIs:** Crizotinib +
-  * **ABL-TKIs:** Imatinib (for BCR-ABL in CML) +
- +
-===== Comparison Table ===== +
- +
-^ Feature                        ^ EGFR Inhibitor                 ^ Tyrosine Kinase Inhibitor (TKI)     ^ +
-| **Target**                     | EGFR                           | Kinase domains (multiple receptors) | +
-| **Includes**                   | mAbs + TKIs                    | TKIs only                           | +
-| **Example (mAb)**              | Cetuximab                      | ✘                                   | +
-| **Example (EGFR-TKI)**         | Erlotinib                      | ✔                                   | +
-| **Broader category**           | No                             | Yes                                 | +
- +
-===== Summary ===== +
-  * EGFR inhibitors = monoclonal antibodies **and** EGFR-TKIs +
-  * TKIs = small molecules targeting **various** kinase domains, including EGFR+
  
  
  • egfr_inhibitor.txt
  • Last modified: 2024/06/07 02:49
  • (external edit)