brain_abscess

Cerebral Chromoblastomycosis: A Unique Presentation of Dematiaceous Fungal Infection in an Immunocompromised Patient

by

In a case report – culture/histopathology confirmed. Norton Stephen et al. from AIIMS Madurai (Madurai), JIPMER Puducherry (Puducherry), Neurosurgery JIPMER Puducherry. published in Annals of Indian Academy of Neurology. to report an unusual intracranial dematiaceous fungal infection (“cerebral chromoblastomycosis”) in an immunocompromised host. Demonstrates that dematiaceous fungi can invade the CNS in immunosuppressed patients, presenting as brain abscesses; underscoring need for high suspicion, tissue diagnosis, and tailored antifungal therapy 1).

Critical Review

1. Novelty & Rigor:

  1. Rare case: cerebral infection by pigmented dematiaceous fungus is exceedingly uncommon. Prior reports mostly in immunocompetent individuals
  2. Methodology strong: pathology plus culture confirmation; however, imaging, antifungal regimen, and clinical course not detailed in provided abstract.

2. Limitations:

  1. Lack of comprehensive clinical data: dose/duration of therapy, immune status specifics (CD4, neutrophils), imaging, follow-up.

    Read more