Day: June 15, 2025

Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice

by

In vivo animal studies

Type of study:: In vivo animal study (murine intracranial aneurysm model) First author:: Dang et al. Author affiliations::

  • Hamamatsu University School of Medicine, Hamamatsu
  1. Dept. of Neurosurgery
  2. Dept. of Anesthesia and ICU
  3. Dept. of Medical Education
  4. Dept. of Pharmacology
  • Asahikawa University School of Medicine, Asahikawa
  1. Dept. of Anesthesia and ICU
  • Hamamatsu Medical Center, Hamamatsu
  1. Dept. of Neurosurgery

Journal:: Journal of Neuroscience Research Purpose:: To evaluate whether dietary resveratrol prevents formation or rupture of intracranial aneurysms via anti‑inflammatory mechanisms. Conclusions::

  • No significant reduction in aneurysm formation incidence
  • Marked reduction in rupture rate (88 % → 40 %, p=0.026)
  • Modulation of inflammatory markers: ↑Sirt1, ↓Nfkb1, ↓Tnf

Citation:: 1)

Critical Review

1. Model limitations The elastase + DOCA‑salt murine model poorly reflects human aneurysm pathophysiology, lacking hemodynamic fidelity. No histological validation of aneurysm similarity or wall integrity is presented.

Read more